Anti-Histamine Protocol for MS management

Disclaimer

Before you read any further – read this. Seriously.
Don’t come crying later that no one warned you.

I’m not your doctor, not a neurologist, not a scientist, and I don’t even own a fancy white coat. I’m just some random dude who got slapped with an MS diagnosis, didn’t get much out of the “standard treatment,” and had to take matters into his own hands.

Everything you’ll find here is my story, my personal experience, and my conclusions. This is not medical advice. This is not a recommendation. And it’s definitely not some kind of magic cure that’ll fix everything.

If you’re already on DMT and it’s working for you – fantastic! Don’t stop. Don’t change a thing just because you read something cool on the internet. That would be seriously dumb.

If you’re not ready to take full responsibility for your life and the choices you make – this site is absolutely not for you.

If at any point you feel your blood boiling from what you’re reading – the best thing you can do is close this site and never come back.

But if you’re here searching for something beyond the usual “Just take this and hope for the best” – then welcome. Just know this: everything you try is your responsibility.

No one’s coming to save you. But maybe… just maybe, you can save yourself.

The Protocol overview

I didn’t set out to create a “protocol.” I was just trying to survive. After years of searching, tracking symptoms, experimenting, trusting my body (and sometimes just dumb luck), I identified the key trigger behind my MS relapses.

Meet histamine. And if you have MS – histamine is not your friend.

This protocol put me into remission. I haven’t had a full-blown MS attack since. And while I’m aware that MS can always come back, this approach gave me back control.

What worked for me came down to three core pillars:

1. Reducing histamine load
2. Healing a leaky gut
3. Lowering systemic inflammation

Now, to be honest – I don’t know if you have to do all three. Maybe just reducing histamine would’ve been enough. But I can say this with confidence: #2 and #3 definitely improved my condition, but they never brought real remission. The turning point only came when I added histamine control into the mix – and it felt like the missing piece.

At this point, I’m not eager to test what happens if I drop it. My lifestyle wouldn’t allow it anyway – and honestly, I’m not willing to gamble on another relapse just to satisfy curiosity.

Reducing histamine load

This is the foundation. The part that changed everything.

You can fix your gut, meditate like a monk, eat organic everything – but if histamine is constantly overflowing, none of that will stabilize MS. At least, not in my experience.

There are three kinds of enemies when it comes to histamine:

1. Foods that contain histamine
2. Foods that trigger your body to release its own histamine
3. Foods (and substances) that block DAO – the enzyme that clears histamine in the gut

You can’t just avoid one of these and hope for the best. You need to address all three.

Foods high in histamine

This is the “easy” part: just don’t eat them.

We're talking about:

1. Aged cheeses
2. Cured meats
3. Fermented foods (sauerkraut, soy sauce, vinegar, etc.)
4. Leftovers (especially meat/fish)
5. Canned fish (especially tuna, mackerel, sardines)
6. Alcohol (more on that below)

This isn’t the full list. So do your homework – Google the rest yourself. (I might put together a full one later if I feel generous.)

DAO enzyme supplements can help a bit if you mess up, but they’re not magic. They’re like a mop – not a dam.

I used to take DAO every meal when I started. Later, I relaxed. But at first – no mercy. If a food hit even one red flag, it didn’t go on my plate.

Histamine liberators (a.k.a. mast cell triggers)

These foods don’t contain histamine. But they make your body release its own.

Examples:

• Citrus fruits
• Strawberries
• Tomatoes
• Egg whites
• Chocolate
• Shellfish
• Pineapple
• Nuts (especially walnuts, cashews)
• Google the rest

Here you want to stabilize your mast cells – those bastards that dump histamine when provoked.

DAO blockers

This is the silent killer. You think you’re eating “safe” food – but it shuts down your histamine clearance. No amount of DAO supplement will save you if you eat histamine-rich food plus something that shuts DAO off. Alcohol belongs here too – it both blocks DAO and often contains histamine itself. Double trouble.

Biggest offenders:

• Alcohol (especially red wine and beer)
• Energy drinks
• Black tea and green tea
• Mate
• Some medications (painkillers, antidepressants, antibiotics)

Combine a DAO blocker with high-histamine food? That’s the perfect storm.

One glass of wine and one aged cheese, and you're basically flipping the “fuck around and find out” switch.

Supplements on this step

• Quercetin + Vitamin C – mast cell stabilization and general inflammation
• Luteolin – mast cell stabilization
• DHA & Omega-3s
• Probiotics (but be careful – see below)

Some probiotics can actually increase histamine – avoid strains like Lactobacillus casei, L. bulgaricus, S. thermophilus. Better ones (histamine-neutral or degrading) are Bifidobacterium infantis, B. longum, Lactobacillus plantarum, L. rhamnosus GG.

Healing the gut (aka fixing the leaky mess inside you)

You can’t fix systemic inflammation if your gut leaks like a cracked pipe. You can’t stabilize immunity if half-digested food is slipping through the gut wall and triggering reactions. And histamine? It thrives in a messed-up gut.

I didn’t believe in “leaky gut” at first either. Then I started fixing mine – and my whole system calmed the hell down. Symptoms shrank. Recovery got faster. Brain fog started clearing.

Here’s what I did – and what worked:

Cut all chemical crap

This was the foundation. No preservatives, no additives, no colors, no mystery powders.
If the ingredients list looked like chemistry class – I skipped it. No E-numbers, no artificial sweeteners, no “natural flavorings.” This step alone made a huge difference.

Cut gluten

Straightforward. No "just one croissant."

• Less bloating
• Less fatigue after meals
• Felt like food was finally being absorbed

Cut dairy

Same story.

• Better digestion
• No more weird stomach noises
• Exception: I can get away with fresh mozzarella or cream cheese sometimes

Switched to low-histamine diet

Once I stacked this on top – boom. Gut stuff cleared up. Brain fog? Gone. Food hangovers? Gone.

How do I tracked progress with the gut? No blood tests. No zonulin.

After years of living with MS, I’d given so much blood for testing you could’ve fed a mid-sized vampire cult. At some point, I just got tired of chasing numbers that didn’t help me feel any better.

Just paid attention:

• Energy dips
• Bloating
• Sleep
• Skin
• Mood
• Brain fog

If you listen carefully, your body stops whispering and starts telling you exactly what's up.

You don’t need to believe in a leaky gut. But you should at least test what happens when you stop stabbing it. Gluten and dairy were not “bad” because someone said so. They were bad because my gut hated them. Your gut is either helping you heal – or helping you relapse. There’s rarely an in-between.

What I noticed? Gut repair didn’t cure MS. Unfortunately.

But it did:

• Improve digestion and energy
• Lower random background inflammation
• Reduce the intensity of flare-ups (before full remission)
• Help supplements actually work

It also helped me spot what triggers me, because the noise from my gut calmed down.

Supplements on this step

• Probiotics – only histamine-safe strains: Bifidobacterium infantis, B. longum, Lactobacillus plantarum, L. rhamnosus GG
• L-glutamine – helped a lot, especially with gut repair, but I started losing weight fast – like, disturbingly fast. At one point I had the unique privilege of hiding behind a broomstick handle. So I dropped it.
• Digestive enzymes – I don’t take them daily, but use them when I eat something heavy or “risky”

Lowering systemic inflammation

Everyone’s obsessed with inflammation these days. Every blog, every protocol, every influencer with a ring light. “Inflammation this, inflammation that.” Even my cat has learned to meow the word. Look – I’m not saying chronic inflammation is good. It’s obviously not. It sucks. It slows healing. It messes with everything. But based on my own experience – inflammation by itself didn’t trigger relapses. After switching to a strict low-histamine diet, I had plenty of chances to screw myself with inflammation. Stress. Sleepless nights. Wrong food. And yep – I did it. Like a dumbass. Many times. And you know what? Not once did that alone cause a relapse.

Usually, your body can handle it. But when that inflammation shows up alongside a high histamine load? Boom – relapse.

I didn’t follow some perfect, influencer-approved anti-inflammatory diet. I tried. Turmeric wrecked my liver –  fatigue, nausea, the works. Some “superfoods” gave me rashes or straight-up knocked me out. So I stopped being cute and just paid attention to what actually made me worse.

I cut the obvious triggers (read: my obvious triggers)

• Chocolate
• Coffee (brutal, but necessary)
• Fried crap
• Even “healthy” stuff like bone broth and homemade yogurt – Avoid. (See My Story for how badly that went.)

That’s why I see inflammation as a co-factor, not a primary trigger. It’s the gasoline – but histamine is the match.

Supplements on this step

• Magnesium glycinate or citrate – helped with sleep, cramps, and stress. One of the few things I’ve taken long-term.
• DHA & Omega-3s – sometimes good, sometimes too much. I learned not to overdo it – less is more.

The Core – if I had to start over

This protocol isn’t about hacks. It’s not about perfection. It’s about removing the three biggest sources of internal chaos that kept me in relapse mode. If I had to start from zero – confused, wrecked, desperate – here’s exactly what I’d do:

Go full “no mercy” on histamine for 3–4 weeks

• Cut everything that contains histamine, triggers release, or blocks DAO
• Take DAO enzymes if you can tolerate them
• Read ingredients like your life depends on it – because it does

Simplify your diet

• Choose 5–10 safe foods and eat them on repeat
• No cheat meals, no experiments
• Not forever – just until your system resets

Calm your gut

• No E-numbers, preservatives, colorants, thickeners, or “natural flavors”
• Cut gluten – even if you don’t have celiac
• Cut dairy – no exceptions during reset
• No fermented BS
• Safe probiotics only
• If it bloats you or gurgles, it’s out
• Don’t fall for the bone broth + homemade yogurt hype → (See “My Story” for how badly that went)

Control inflammation

• Cut obvious triggers: chocolate, coffee, fried crap
• Watch stress like a sniper
• You don’t need to live like a monk, but you can’t keep lighting fires and pretending you’re fireproof
• Inflammation alone didn’t cause my relapses, but combined with histamine? Relapse as a gift.

What I Took (Not what you have to)

• Quercetin + Vitamin C
• Magnesium (glycinate or citrate)
• DHA/Omega fats
• Luteolin
• Probiotics (only histamine-safe strains)
• L-glutamine
• Digestive enzymes

How Long Does It Take?

Let’s be real – you spent years wrecking your system. You’re not going to fix it in a weekend.

Everyone’s different. It depends on how strict your diet is, how much chaos you remove, and how far off the cliff you already are. But if you want a ballpark, here’s how it went for me:

• Histamine baseline – about 2–3 months. No mercy. Clean diet, no triggers, DAO enzymes. I saw results when I actually committed.
• Gut repair – around 6 months. But that’s after years of being on what I thought was a “healthy” diet. Turns out, I was just feeding the fire differently.
• Inflammation – quieted down over time. Once the gut calmed and histamine dropped, background noise faded.

You don’t need to be perfect. But you do need to be consistent.

You’ve been building this wreck for decades. Now you want to rebuild it in a week? You’re going to have to rethink your whole damn life.

And honestly? That’s a good thing.

Next: No Woo. Just Studies.